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KMID : 0366319910110030186
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Biochemistry and Molecular Biology News
1991 Volume.11 No. 3 p.186 ~ p.191
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Abstract
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Only within the last decade have been obtained that support the concept of an interaction between Zn and vitamin A. A consistent and established finding is a reduction of plasma vitamin A concentration in Zn-deficient animals despite diet adequate in vitamin A. There is no consistent oppinion about the reason why plasma vitamin A level are depressed in Zn-deficient animals. Zn deficiency was a contributing factor in the failure to synthesize or release RBP, and consequently to mobilize hepatic vitamin A stores into the plasma. Several enzymes involved in protein synthesis such as thymidine kinase and DNA-dependent RNA polymerase are known to be dependent on Zn for their activity. Possibly one or more enzymes specific for RBP synthesis is also Zn dependent. In contrast, other concluded that low plasma vitamin A levels in Zn deficiency are probably the result of growth retardation rather than any direct role of Zn in vitamin A metabolism.
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